Adam and Eve have been lovers for centuries. Both are cultured intellectuals with an all-embracing passion for music, literature and science, who have evolved to a level where they no longer kill for sustenance, but still retain their innate wildness. Adam, a reclusive underground musician hiding out in the ruins of contemporary Detroit, despairs about human civilization’s decline, and worries about future survival. Eve, who is perhaps 3000 years old to Adam’s 500, takes a longer view of history and is more optimistic. She leaves her home in the ancient city of Tangier to come to his side. As blood has been tainted by the zombies (humans), the formerly immortal Adam and Eve must secure uncontaminated blood from hospitals or they will perish. Eve’s close friend, Christopher Marlowe, is an elder vampire who provides Eve with hospital blood. Adam gets his supply from Dr. Watson, a skittish hematologist who provides safe blood at a price. Adam and Eve’s precarious footing is further threatened by the uninvited arrival of Eve’s carefree and uncontrollable little sister Ava. Unlike Adam and Eve, Ava hasn’t yet learned to tame her wilder instincts, and her recklessness concerns Adam.