Dodge City, known as the Sodom and Gomorrah of the plains, is a typical frontier city of the late 1800s with typical problems ranging from rumored Indian raids to bank and stage robberies, cattle rustling, and family feuds. All of these must be dealt with within the law and that task falls to Matt Dillon, US Marshal (James Arness).
Dillon is a man who prefers the use of logic over the use of the gun but the nature of the people passing through Dodge doesn't always leave him that choice. Aided by various assistants and deputies over the years (played by Dennis Weaver, Burt Reynolds, and Ken Curtis), he does his best to keep the lawless element out of his town and his territory. Matt often solves his crimes through keen observation and deduction, an innovative approach for the times.
Crucial information about cases is often provided by his beautiful companion, Long Branch owner Kitty Russell(Amanda Blake), while they drink beer or whiskey in her establishment. Matt also often exchanges banter or bounces his theories off of the crusty town doctor, Galen Adams (Milburn Stone).