Description: Masters of Sex is a Showtime series features Michael Sheen and Lizzy Caplan as the real-life pioneers of the science of human sexuality, William Masters and Virginia Johnson. The series chronicles their unusual lives, romance and pop culture trajectory, which saw them go from a Midwestern teaching hospital to the cover of Time magazine and Johnny Carson's couch. Masters, which also stars Caitlin Fitzgerald, Nicholas D'Agosto and Teddy Sears, is an adaptation of Thomas Maier's book, Masters of Sex: The Life and Times of William Masters and Virginia Johnson, The Couple Who Taught America How to Love.