Murder seems to follow Jessica Fletcher, a former English teacher and a mystery writer full of charm, zest-for-life, and personality; who happens to become "the investigator" when traveling around the country to promote a series of novels. Murder always occurs when she is present. Even in Cabot Cove!
Although Angela Lansbury was the only regular character throughout the series entire run, she was frequently joined by a number of recurring and special guest stars, including Tom Bosley as Sheriff Amos Tupper in the early seasons and Ron Masak as Sheriff Mort Metzger in the later seasons, William Windom as Dr. Seth Hazlitt, Michael Horton as her nephew Grady Fletcher (one of her many, many relatives), and from time to time Jerry Orbach would appear as private eye Harry McGraw. Orbach's role later led into a short-lived spin-off, The Law & Harry McGraw.
The series aired a total of 263 color episodes from 7 October 1984 through 19 May 1996 and five telemovies (including the pilot movie, which aired in September of 1984).
As of the fall of 2009, 10 seasons have been released on DVD, with the 11th season due to be released in early 2010.