Based of the manga Okami to Koshinryo by Isuna Hasekura. Spice and Wolf is about a 25 year old peddler name Craft Lawrence who finds a mysterious and beautiful girl named Horo sleeping in the back of his wagon. He is surprised to find that the girl has ears and a tail and howls when she wakes up. He soon learns that she is the harvest god of the nearby village Pasroe and she wants to return to homeland in the north called Yoitsu. Horo manages to get Lawrence to take her with him and in turn helps him earn more then he did before. Little do they know, the church is watching the two very closely.