CO CDR Tom Chandler and his crew find themselves in a whole new world when the ship's scientist passenger, Dr. Rachel Scott, reveals that the entire planet is in their hands.

Chandler and his crew head to the U. S. Military base at Guantanamo Bay in hopes of collecting food, medical supplies and fuel replenishments.

The James faces off against a new foe who demands Chandler hand over Rachel and her research.

Mechanical problems leave the ship with a severe shortage of drinking water.

With Rachel close to a breakthrough on her vaccine, she, Chandler and XO Slattery lead a small team into the jungles of Nicaragua on a mission to find monkeys for her vaccine trials.

With monkeys for testing, they work towards a vaccine but with no cure in sight, a serious lack of monkeys and increasingly depressing distress calls, they think about returning to Nicaragua.

After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leaves Chandler and Tex stranded at sea.

With Chandler and Tex held prisoner on the Russian ship, it is up to Slattery to devise a plot to free them.

With a potential cure in their grasp, Dr. Scott asks for human volunteer's to test her formula that was successful on a monkey. However, will this be the answer she is looking for, or will it put the volunteers' lives in jeopardy?

The crew of the USS Nathan James arrive in Baltimore with the cure expecting a welcoming committee, but what they find is something else entirely.