In Nice, Frank is hired by Dieter's friend Trina to deliver an engine prototype to the Paris Motor Show. They race towards Paris but are pursued by an assassin nicknamed The Wolf. Unfortunately the prototype emits a trackable GPS signal.

Frank's latest job goes completely wrong: he loses his package in a holdup and is accused by his Russian gangster employer of having embezzled the money.

The Transporter's package is a beautiful young woman who's caught in the crossfire between her disgraced General father, and the criminal syndicate hunting him.

Frank faces a dilemma when he finds out his package is a heart meant for transplantation stolen by his crime lord client to save his own son and when Inspector Tarconi informs him that another dying boy is waiting for it at the hospital.

In Philadelphia, Frank meets Jack Perkins, his CIA instructor. The blind man is being framed for leaking secret documents. Frank must find a USB key containing evidence that can clear Jack's name and reveal the real mole's identity.

Frank is given a 12 hour deadline to transport a new nano-microchip.

Frank finds himself in Toronto, Canada doing a job for a security company.