- Publisher: Nicalis
- Release Date: Oct 30, 2015
- Also On: PlayStation 4, Xbox One

- Summary: When Isaac’s mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement facing droves of deranged enemies, lost brothers and sisters, his fears, and eventually his mother.
- Developer: Nicalis
- Genre(s): Action, Shooter, Shoot-'Em-Up, Top-Down
- Cheats: On GameFAQs
- More Details and Credits »
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Score distribution:
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Positive: 9 out of 10
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Mixed: 1 out of 10
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Negative: 0 out of 10
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Nov 8, 2015New items, new challenges, a new character, new room layouts, new bosses, new transformations, new soundtrack, new floors, and the list goes on. This is the expansion we were hoping for. Nicalis did us a solid and stuffed a disgusting amount of content in a game already bursting with disgusting content. Now if you’ll excuse me, I’m going to kill Mother for the thousandth time.
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Nov 3, 2015There's a lot to love about The Binding of Isaac: Afterbirth. It's a great expansion to a great base game. If you enjoyed Rebirth, you'll love Afterbirth.
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Nov 4, 2015We now have a complete, perfect version of The Binding of Isaac, one which, it seems, can sustain no further refinement.
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Nov 13, 2015McMullen did it again. With the latest expansion The Binding of Isaac got bigger, better, and it became even more of a virtual drug (if that was even possible). It’s a disturbing game, but also one that needs to be played, and slowly analyzed. Room after room, trauma after trauma, forever and ever.
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Nov 23, 2015The Binding of Isaac: Rebirth is packed with content and knows like no other 2D game how to turn a gloomy atmosphere down.
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CD-ActionFeb 4, 2016McMillen’s dungeon is really worth revisiting. Afterbirth does not introduce any spectacular changes but offers tons of new content. [01/2016, p.73]
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Dec 29, 2015In contrast to the previous expansion, Afterbirth is just a collection of scraps and trimmings that has nothing original to offer.
Score distribution:
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Positive: 20 out of 24
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Mixed: 3 out of 24
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Negative: 1 out of 24
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Nov 7, 2015
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Oct 5, 2017
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Feb 17, 2016
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Feb 22, 2019
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Nov 21, 2015
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