We follow the journey of James Cole, a time traveller from a post-apocalyptic future, who heads to the present to stop a plague that will eventually decimate the human race.

Time Traveller James Cole's search for information about a mysterious organisation known as the Army of the 12 Monkeys leads him to a mental institution in 2015.

Cole is led to Haiti in 2014, where a dangerous outbreak proved to be a devastating moment in Dr. Railly's life.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room -- an off-site, black ops lab that houses the virus that will one day destroy the world.

After the events in the Night Room, Cole automatically returns to 2043 and finds that the timeline has been altered. He meets Jones, who has no idea who he is.

Cole, Railly and Aaron race to stop the virus from being deployed as a bio-weapon in Chechnya.

The Core that powers the time machine is fading. To get Cole back from the past, Jones must convince her former colleagues at the military operation "Spearhead" that her mission is worth saving.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Forces come to a head when Ramse takes measures to protect his newfound family, leaving Cole to deal with the fallout.

Cole splinters to Tokyo in 1987 in a last chance effort to stop the Army of the 12 Monkeys.

With Cole dying from the effects of time-travel, Railly must find the one person who can save him.

Cole and Cassandra try for a final confrontation with the Witness, while Jones faces a new threat to the mission.