A bipolar neuroscientist humanely deals with a manic teen who has a brain tumor and a woman with dementia. Her boyfriend proposes but, struggling with her desire to live life to the fullest, she sabotages things by tossing out her meds.

A brain surgeon kills his patient when he has a seizure during surgery; a young girl hallucinates that her head explodes; Dr Black tries to help but are lies in her way? Her boyfriend confronts her for the truth.

Ali discovers that Leo, Dr. Bickman's rival, doesn't have super-memory but is faking it due to a brain tumor. A new patient turns violent. Dr Black loses her ring before her engagement party.

Dr Black treats Jacob, a rich Jewish man with God delusions; Arthur relapses so Dr Black gives him hallucinogenic mushrooms. Dr. Lark, who refuses to leave the office, gets an ultimatum from her date.

Dr. Black treats a man with phantom limb pain and a blind woman with visual hallucinations. Her brother tries to get Cat to reconnect with their dad but she resists. Dr. Bickman tells Leo the truth about his memory loss.

Ian and Catherine work to remove a bullet from a Pulitzer Prize-winning journalist without help from modern technology. Meanwhile, a high-profile makeup artist suffers a minor stroke leaving him color blind; and Catherine meets Will's parents.

The Cube is under attack by a violent gunman hounded by voices; Dr Bickman must operate on his shooter. Dr Black treats a patient with alien-hand syndrome and Will suspects she is lying when she cancels their date.

Trying to help a sax player with hand tremors who fears brain surgery, Dr Black introduces him to her musician father. Leo begs Ian for a letter of recommendation and Catherine declares her feelings for him.

Dr Black refuses to give up on a girl dying of rabies. She goes manic while searching for a cure and returns Will his engagement ring, this after he'd told her he'd finally fired his mistress Delilah.

A doorman collapses, so Dr. Bickman rushes him to the cube and performs an alternative procedure. Meanwhile Catherine gets depressed after making a tough diagnosis. Joshua fears he's enabling his sister.

Catherine returns to work after a month in treatment but can she keep her job? Esme's biological father needs his daughter's help and Esme finds out about the adoption.