Guest Jessica Simpson discusses her recent weight loss; Sheryl Crow, who came up with the theme song for the show, also joins.

Graduate student Aimee Copeland tells of losing parts of all of her limbs to a rare flesh-eating bacteria; Katie takes a lap around the Indianapolis NASCAR driver Danica Patrick.

After the East Coast is slammed by Hurricane Sandy, Katie sits down to talk with those who experienced it full force.

Millions of girls need help across the globe, but they also need help right here at home. By the age of 18, one in four girls in the U.S. will be sexually abused.

Celebration of the 50th anniversary of General Hospital (1963).