When an American aid worker is killed in Syria by the first known American ISIS leader, Elizabeth recalls all aid workers stationed there including her brother, Will, and makes it her mission to get justice for the victim.

With the support of President Dalton, Elizabeth attempts to get the Senate's support for a history-making effort to lift the Cuban trade embargo. Also, Henry and Alison bond while touring Havana together.

Shortly before Elizabeth is to deliver a speech at the United Nations accusing Russia for the attack on Air Force One, Henry shares information that makes her reconsider her theory.

Elizabeth and President Dalton discover a secret that could impact Maria Ostrov's reputation; Dmitri wants to stop being a spy.

After the death of Maria Ostrov, Elizabeth works to maintain a fragile peace. Henry is in grief over the loss of his student Dmitri. Efforts are made to save American astronauts.

Elizabeth heads to Myanmar to finalize an important trade agreement. There, she deals with a conflicted American ambassador and a hostage situation. At home, she and Henry fend against neighbors' complaints.

After Henry's father dies, painful and shocking family secrets are uncovered; Russell decides to keep significant information from Elizabeth's team.

Elizabeth deals with extremely sensitive issues in Saudi Arabia as she oversees a mission to find those responsible for a uranium heist Eastern Europe.

Following a shocking event on U.S. soil, Elizabeth rushes to find answers to President Dalton's many questions about how it was able to occur.

While Elizabeth accompanies Alison on a college campus tour, she is ambushed by protesters about a Chilean mining operation involving the U.S. and Chilean government. Also Henry attempts to track down Jibral Disah's third wife, Hijriyyah.

Henry, Jose & Jane are sent to Pakistan on a dangerous mission, when POTUS receives word that Disah is in Islamabad and may be receiving direct assistance from the Pakistani government

The United States debates enacting a "render safe" mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disa.