Starfleet must once again call on legendary Jean-Luc Picard after members of his former crew - Cristóbal Rios, Seven of Nine, Raffi Musiker, and Dr. Agnes Jurati - discover an anomaly in space that threatens the galaxy.

Picard finds himself transported to an alternate timeline in the year 2400 where he must face one last trial orchestrated by his longtime nemesis Q.

Picard and the crew travel back to 2024 Los Angeles in search of the one person who can help them identify the point at which time diverged.

With time running out to save the future, Picard seeks out an old friend for help; Rios winds up on the wrong side of the law; Jurati makes a deal with the Borg Queen.

Picard discovers an important person from his past, Q continues his manipulation of the timeline, taking an interest in Dr. Adam Soong. Seven and Raffi attempt a daring rescue of Rios.

Tallinn helps Picard and the crew infiltrate a gala on the eve of a joint space mission to protect an astronaut they believe is integral in restoring the timeline - Renee Picard; Kore makes a startling discovery about her father's work.

Tallinn enters Picard's subconscious mind to help him wake from a coma and face his deepest fears; Seven and Raffi search for Jurati fearing she's succumbed to her inner monster; Rios struggles to hide the truth about himself from Teresa.

With time running out before the launch of the Europa Mission, Picard and Guinan must free themselves from FBI custody. Seven and Raffi come face-to-face with Jurati and the horror of what she's become.

Picard must face the ghosts of his past when he and his crew are attacked by a new incarnation of an old enemy; Seven and Raffi face Jurati in a final showdown.