The King of France revenges himself on King Alfonso of Naples for the plague, and after finding pornographic frescoes the Pope decides to revive Roman bacchanalia.

Paolo searches for Lucrezia and their son, and the Pope inspects the lives of commoners with Vittoria and Guilia in disguise.

Lucrezia is inconsolable after Paolo's death, but it is ruled a suicide as King Charles marches north to revenge themselves on the Pope and the Eternal City.

Cesare learns that Ursula and others at the convent have been slaughtered by the French, and he plans revenge as the Pope organizes a coalition to attack the retreating French.

Cesare goes to Forli to convince Catherina Sforza to pledge allegiance to the Pope while the Pontiff tries to find a way to buy off Cardinal Savarona.

Machiavelli gives Cesare information on De Medici gold, and Rodrigo pressures Lucrezia into another political marriage.

Juan returns from Spain with gifts after contracting a STD. He lays siege to Forli and takes Cathrina Sforza's son hostage.

The Pope excommunicates Friar Savanarola and he fails a test by fire while Giovanni haunted by shame and the agonies of syphilis threatens Lucrezia's son.

Pope Alexander authorizes a search for missing son Juan as Savonarola continues to resist torture, and Lucrezia seduces her fiancé.