Vanessa Helsing, a distant relative of the famous vampire hunter Abraham Van Helsing is resurrected, but soon realized that the world was conquered by vampires.Tya is humanity's last hope to lead people to regain their lost.

In the days leading up to "The Rising," Vanessa is attacked and left for dead by an intruder. When Doc discovers anomalies in Vanessa's bloodwork, Axel and the marines come to retrieve the body, only to become marooned in the hospital.

Vanessa and Axel lead the others in the hospital's last stand against a siege by Julius and his vampire soldiers. Later when Dmitri's vampire 'Death Squad' arrives, it looks like civil war is brewing among the two vampire factions.

Vanessa, Susan, Mohamad and Sam take refuge in the house Susan grew up in. Mysteries finally begin to reveal themselves to the dwindling group.

Sam hunts for Vannesa and Mohammad. A confrontation occurs Julius and Dmitri. The resistance plans a last counterattack.

Somebody from the past who was a guardian of Jenna will make an appearance.