Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of "the hybrids," an army of unstoppable lab-made creatures focused on destroying mankind.

Jackson, Logan and Tessa's hunt for Abigail becomes dangerous when new hybrids appear. Abe and Dariela search for their son.

Abe and Dariela ponder over making a deal that will betray their friends. Abigail's game of cat and mouse continues. Clementine's past catches up to her.

While Jamie's under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans.

As the team launches a rescue mission for Issac, Jaime and Mitch hunt for a large snake creature. Abigail's master plan comes to light.

Abigail holds Jackson prisoner in order to extract information from him that is critical to her secret master plan, and the team faces a mid-air crisis when their plane experiences an electrical malfunction.

After Mitch's alter ego, Mr. Duncan, attacks the team's plane then flees, Jamie, Abe and Max set out to find him and help.

Logan tries to destroy the hybrid nests before they activate. Clem's pregnancy undergoes a surprising development. The team tries to perfect the cure using Abigail and the hybrids.

As the team is trapped inside the plane by toxic spores surrounding them, complications arise during the delivery of Clementine's baby.

After the team's plane suffers a catastrophic accident in the hybrid zone, Dariela and Tess set out on a rescue mission to save them.

The team races to stop the hybrids from breaching the barrier wall by shutting down the last beacon that draws them in.