Three years after he recovered The Ark of the Covenant. Jones recovered an artifact that he found as a kid, the Cross of Francisco De Coronado from treasure hunters. Now, Jones discovers the history of another biblical artifact called "The Holy Grail". He was also informed that his father, Henry Jones is missing. Jones has to find his father who is looking for the Grail. However, Jones will become involved in the search of the Holy Grail along with his father, as well as fighting the Nazis to reach it.