Laurel continues her investigation of Dr. Daudier's death, while more citizens are infected by the bugs; Dr. Daudier's daughter and Gustav Triplette begin to question what is happening.

Agent Onofrio's investigation of a deadly incident on live TV causes Laurel, Gustav and Rochelle to delve deeper into the bug mystery. Luke tries to hide his affair with Scarlett.

When the Center for Disease Control has its funding temporarily cut, Luke attempts to reach a compromise to have the money reinstated, but Red's political machinations undermine him at every turn.

Laurel comes under investigation about her potential involvement with the bug infestation. Also, Gustav and Rochelle discover a unique way to communicate with those infected by the bugs.

Rochelle and Gustav capture and question a man they suspect is infected by the bugs. Also, Luke and Red face off in a Senate Intelligence meeting about a potential war.

Laurel must work alongside an old boyfriend, Ben Valderrama, when Luke enlists her help in putting together a political documentary to support his anti-war initiative. Also, Laurel worries about the health of Luke and Germaine's baby.

Luke and Laurel rush to uncover Red's secret agenda, which is buried in a massive new budget bill. Also, Gareth inadvertently witnesses an unsettling bug encounter in Red's office.

Laurel discovers the secret to driving the bugs out of a person's brain and tests the tactic on her father. Armed with new knowledge, Laurel and Gareth attempt to expel the Queen bug out of Red's head once and for all. Laurel and Gareth progress in their romantic relationship.