Ang receives devastating news that exposes the cracks in her marriage with Neil. Brittany's issues with Renee and Carla create a stronger alliance with Drita. A troubling rumor reopens the toxic feud between Drita and Karen.

The war between Karen and Drita reaches irreparable heights when Brittany relays an explosive rumor. The women work to cheer Ang up as she faces yet another life threatening surgery. Renee takes up a new hobby.

The feud between Drita and Brittany and Karen and Marissa explodes in a violent table meeting. Big Ang's cancer returns. The wives reminisce about their trials and tribulations in Staten Island as the series comes to a close.