Description: Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame (appearing in 600 newspapers in over 20 countries) to big screen stardom. In this family comedy event, the "Duke" is living large in Orange County, California. But fitting in with his new four-legged friends – and a potential romantic interest -- isn't always easy for a super-sized teenage dog. (20th Century Fox)