Bonnie refuses to let her dogs outside, turning her home into an unsanitary horror that is threatening her health - and the animals. Don's 30 cats create a health hazard that forces his wife from their home.

After Janice's estranged husband cuts off support for her 87 dogs, her family is forced to step in. JD and Patti's 20-year relationship is threatened when JD refuses to stop rescuing unwanted pets.

Friends step in when disease threatens Lolette's 250+ cats, while a house packed with animals and junk pushes Robin's husband to the brink of divorce.