Father Morrissey hits an extortionist in a hit-and-run, but a girl picks up the extortion evidence. When he is taken to the hospital, Morrissey fakes sickness to get near him. Dr. Mark Sloane finds the priest's behavior suspicious.

Security is high at the hospital because of Chairman Basset, a high profile patient whose life has been threatened by the mob. A female assassin feigns amnesia from an accident to get near Basset, and she kills a nurse who recognizes her.

A comedian who was hosting a telethon for the hospital is murdered, so Sloan investigates.

A millionaire dies after declaring his intention to leave his money to the hospital - and Sloan suspects the man's offspring.

Before dying of a gunshot wound, a long-time patient gives Mark a winning lottery ticket, asking him to do some good with it. Several people step forward to claim the lottery winnings, which makes each of them a suspect in the murder.

Steve is framed for the murder of an internal-affairs officer.

Sloan and Jack use connections to the underworld to figure out who set up Steve for murder.

Dr. Sloan witnesses the suspicious death of a financial con man. However, the body disappears, with only his personal diary remaining. Mark must prove that he is dead, while his wife and associates claim that he is just away on business.

Sloan works to clear a friend in the murder of a magician.

While dancing a routine with Mark, dance studio owner Roland Spear dies when a prop cane short circuits his pacemaker. Mark and Steve research who had opportunity to sabotage the cane, with Roland's partner Sammy the leading suspect.

One of Amanda's college friends was planning to publish an embarrassing tell-all book about their college days, which someone in the group was willing to kill to prevent its publication.

Jack's old friend, Sandy, is a high priced call girl. Sandy intends to retire by blackmailing three wealthy clients, and she left evidence with Lily. When Sandy is found murdered, Mark and Jack race to find Lily before the murderer.

The mayor's wife leaves an extravaganza with a fake migraine, engineering a scheme to kill her husband and frame a crackpot. The next day Mark questions her story after he treats a bum who was injured in a hit-and-run near the incident.

Con man Chet Brooks borrows Jack's car and dies in a suspicious accident. Mark spends a weekend at the Nirvana spa where Chet last worked to determine who might have wanted to kill him, while Jack investigates Chet's seedy past.

Convict Paul Dunbar takes a hostage and demands to talk to anchorman Jordan Sanders. Before the interview can take place, Sanders is assassinated and Dunbar killed. Mark uses Dunbar's last words to investigate who might have killed them.

On the eve of his daughter's wedding, Martin Garfield is killed when an earthquake severely damages his home and an armoire falls on him. Mark and Steve find the body and deduce that he had been killed before the earthquake.

While Steve is staking out hit man Bruno, Mark sees him collapse, and quarantines him for the plague - but while the obnoxious virologist says it's from the rodents aboard his cargo ship, it's Mark who smells a rat. After some digging he finds 3 of the crime family's ladies who had a reason to rub Bruno out (tampering with his asthma medication) - so was it (wo)man or beast who killed Bruno?