Three months after freeing Santanico from the Titty Twister, the Gecko Brothers are still on the run. Seth and Kate are lost in Mexico, while Richie and Santanico plot vengeance on the culebra Lord who imprisoned her.

Seth and Kate attempt to pull off a heist, while Ranger Freddie Gonzalez confronts nightmarish visions. Back at the Twister, Carlos's emergence from the Labyrinth sets Malvado's plans into motion.

Richie and Santanico pose as sex traffickers to infiltrate Malvado's food supply, while Sonja forces Seth to kick his drug habit. Meanwhile, Freddie faces off with Sex Machine, who attacks his family to retrieve the codex.

Kate hunts down Scott in Bethel before he can exact revenge. In Houston, Richie and Santanico find themselves deep in the flesh trade, while Seth tries to get back in Uncle Eddie's good graces.

Richie and Seth call a truce and work together to find Malvado's headquarters. Carlos, unhinged from the Labyrinth, abducts Santanico and claims her for himself. And Kate enlists Freddie's help as she attempts to save her brother.

Following the trail of the mass grave, Freddie and Kate uncover an epic secret... and find themselves trapped in the cellar of Oculto, one of the more reclusive - and dangerous - Lords of the Night.

With Uncle Eddie's help, Richie and Seth hatch a plan to complete Santanico's revenge and walk away with the score of a lifetime. Meanwhile, Freddie and Kate find themselves facing an unexpected foe after Malvado's attack.

As the pieces of the big job fall into place, the uneasy trust between brothers and partners crumbles in the light of betrayals and new loyalties.

Santanico confronts Malvado with Seth's help, while Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.

Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado's empire and unleash culebra frenzy on the world.