John interviews Jerry Seinfeld, wildlife advocate Tony Tucci, Ray J, and Stavros Halkias. St. Vincent performs. A fisherman and billboard-poster are interviewed. John and comedian friends go house hunting.

A diverse lineup of guests, including Jon Stewart, Andy Samberg, Gabriel Iglesias, Mae Martin, and tree expert Amanda Begley, share the stage with John. Warren G performs as the musical guest.

John chats with Nate Bargatze, Patton Oswalt, Earthquake, helicopter reporter Zoey Tur and Marcia Clark. Joyce Manor performs.

John talks to David Letterman, Dr. Lucy Jones, Luenell, Bill Hader, and Pete Davidson. Los Lobos perform. Cedric the Entertainer does a makeover. A tennis player and earthquake survivor are interviewed. Brian Grazer tell stories to kids.

With Hannah Gadsby, filmmaker John Carpenter, Mike Birbiglia, George Wallace, Flea, Nikki Glaser, Dr. Emily Lindsey and Beck.