The British actor and comedian steps into late night, taking the reins from previous host Craig Ferguson. Guests for the premiere are Tom Hanks (Bridge of Spies (2015) and (Ithaca (2015)) and Mila Kunis (Jupiter Ascending (2015)).

Patricia Arquette (CSI: Cyber (2015)); Chris Pine (Into the Woods (2014)). Also: Modest Mouse perform.

Kevin Hart and Will Ferrell (Get Hard (2015)). Also: Leon Bridges performs.

David Beckham; Claire Danes (Homeland (2011)); Bob Odenkirk (Better Call Saul (2015)).

Katie Couric; Jeremy Piven (Entourage (2015)); Emmy Rossum (Shameless (2011)). Also: Olly Murs performs.

James does a show from a local residence, welcoming Jeff Goldblum (Portlandia (2011)), musician Beck and Rick Schwartz of the San Diego Zoo.

Rainn Wilson (The Boy (2015) and Backstrom (2015)); Jordana Brewster (Furious 7 (2015)); musician Dave Grohl. Also: Saint Motel perform.

Rob Corddry and Megan Mullally (Childrens Hospital (2008)). Also: comedian Tig Notaro performs.

James Van Der Beek (CSI: Cyber (2015)); Josh Gad (The Comedians (2015)). Also: Jessie Ware performs.

Erin Foster and Sara Foster (Barely Famous (2015)); Christoph Waltz (Tulip Fever (2017)). Also: George Ezra performs.

Author Jon Cryer ("So That Happened"); comedian Grace Helbig; Freida Pinto (Knight of Cups (2015)). Also: Andy Grammer performs.

Model Naomi Campbell; Nick Kroll (Kroll Show (2013)); Katharine McPhee (Scorpion (2014)).

Simon Cowell; Michael Douglas. Also: Jenny Lewis performs.

Rosario Dawson (Daredevil (2015)); Tony Hale (American Ultra (2015)); Sharon Osbourne (The Talk (2010)).

Musician Mark Ronson; Kristen Stewart (Still Alice (2014) and American Ultra (2015)); Betty White (Hot in Cleveland (2010)); Ben McKenzie (Gotham (2014)).

Director Courteney Cox (Just Before I Go (2014)); Oscar Isaac (Star Wars: Episode VII - The Force Awakens (2015)); Joel McHale (Community (2009)). Also: Natalie La Rose performs.

Jason Alexander; Beth Behrs and Kat Dennings (2 Broke Girls (2011)). Also: Estelle performs.

Julie Chen Moonves (The Talk (2010)); chef Gordon Ramsay. Also: The Ting Tings perform.

Anna Faris (Mom (2013)); Tituss Burgess (Unbreakable Kimmy Schmidt (2015)); author David George Gordon.

Russell Crowe (The Water Diviner (2014)); Kathryn Hahn (Happyish (2015)); Eddie Izzard (Powers (2015)). Also: Kodaline perform.

Idina Menzel (Frozen Fever (2015) and Glee (2009)); Kumail Nanjiani (Silicon Valley (2014)). Also: Manic Street Preachers perform.

Arnold Schwarzenegger (Terminator Genisys (2015)); Whitney Cummings (2 Broke Girls (2011)). Also: Gavin James performs.

LL Cool J (Lip Sync Battle (2015) and NCIS: Los Angeles (2009)); Kaley Cuoco (The Big Bang Theory (2007)). Also: OK Go perform.

Dana Carvey ("Live From New York") and The Comedy Club (2021)); Elizabeth Olsen (Avengers: Age of Ultron (2015)).

Helen Hunt (Ride (2014)); Nicholas Hoult (Mad Max: Fury Road (2015)).

Mark Harmon (NCIS (2003)); Zoe McLellan (NCIS: New Orleans (2014)).

Susan Sarandon (3 Generations (2015)); Brooklyn Decker (Grace and Frankie (2015)). Also: Tori Kelly performs.

James Marsden (The D Train (2015) and (Accidental Love (2015)); Kat Graham (The Vampire Diaries (2009)). Also: Brandon Flowers performs.

One Direction perform.

Anna Kendrick, Brittany Snow and Hailee Steinfeld (Pitch Perfect 2 (2015)). Also: The Filharmonic perform.

Sam Rockwell (Poltergeist (2015)); Rebecca Romijn (The Librarians (2014) and Larry Gaye: Renegade Male Flight Attendant (2015)).

Lisa Kudrow (Web Therapy (2011)); Zach Woods (Silicon Valley (2014)); rock climber Ashima Shiraishi.

Halle Berry and Jeffrey Dean Morgan (Extant (2014)).

Hannah Simone (New Girl (2011) and (Flock of Dudes (2016)); comedian Pete Holmes. Also: Noel Gallagher performs.

Guy Pearce (Holding the Man (2015) and Results (2015)); Connie Britton (American Crime Story (2016) and Nashville (2012)).

Allison Janney (Mom (2013)); Jerry Ferrara (Entourage (2015)); Paul Dano ("Love and Mercy" (2014)).

Elizabeth Banks ("Love and Mercy" (2014)); Jane Fonda and Lily Tomlin (Grace and Frankie (2015)).

Nick Offerman (Welcome to Happiness (2015)); Ellie Kemper (Unbreakable Kimmy Schmidt (2015)); Thomas Middleditch (Silicon Valley (2014)). Also: Palma Violets perform.

Betty White (Hot in Cleveland (2010)); Kyle MacLachlan (Agents of S.H.I.E.L.D. (2013) and Twin Peaks (2017)).

Chris Pratt, Bryce Dallas Howard and Jake Johnson (Jurassic World (2015)).

David Duchovny (Aquarius (2015)); Kit Harington (Game of Thrones (2011)). Also: Tamia performs.

Melora Hardin (Self/less (2015) and Do It Yourself (2014)); Amy Landecker (Project Almanac (2015) and Babysitter (2015)). Also: Jack Antonoff performs.

Kathy Griffin (Being Canadian (2015)); Derek Luke (Empire (2015) and Self/less (2015)). Also: The Lone Bellow perform.

Jessica Szohr (Ted 2 (2015)); Aasif Mandvi (Halal in the Family (2015)); comedian Nick Thune.

Carla Gugino (Wayward Pines (2015) and San Andreas (2015)); comic Chris Hardwick.

Soccer player Carli Lloyd; comedian Chris Tucker; Judy Greer (Ant-Man (2015)).

Jim Gaffigan (The Jim Gaffigan Show (2015)); Shiri Appleby (UnREAL (2015)). Also: Best Coast perform.

Cat Deeley (So You Think You Can Dance (2005)); rapper Kid Cudi; father-daughter beatboxers Ed Cage and Nicole Paris.

Ian McKellen (Mr. Holmes (2015)); James Wolk (Zoo (2015)). Also: Adam Lambert performs.

Christina Hendricks (Mad Men (2007)); Laverne Cox (Orange Is the New Black (2013)). Also: Cody Simpson performs.

Chris Colfer (Glee (2009)); Paula Abdul; comic Steve Byrne.

Denis Leary (Freaks of Nature (2015) and Sex & Drugs & Rock & Roll (2015)); Kristin Chenoweth (Descendants (2015)). Also: American Authors perform.

Cobie Smulders (Agents of S.H.I.E.L.D. (2013)); director Judd Apatow (Trainwreck (2015)); Mark Duplass (Togetherness (2015)). Also: Life of Dillon perform.

Mark Ruffalo (Avengers: Age of Ultron (2015)); Amy Smart (Zoey to the Max (2015)); Jason Schwartzman (Wet Hot American Summer: First Day of Camp (2015)).

Comedian Trevor Noah; Odette Annable (The Astronaut Wives Club (2015)); Eric Idle (Absolutely Anything (2015)).

Felicity Huffman (American Crime (2015) and Stealing Cars (2015)); comedian Hannibal Buress (Band of Robbers (2015)). Also: Twin Shadow performs.

Christina Applegate (Vacation (2015)); Christian Slater (Mr. Robot (2015)). Also: Elle King performs.

Matt LeBlanc (Episodes (2011)); William H. Macy (Shameless (2011)); Don Cheadle (House of Lies (2012)).

Chef Gordon Ramsay (Hell's Kitchen (2005)) and his daughter, Matilda Ramsay (Matilda and the Ramsay Bunch (2015)); Josh Charles. Also: Milky Chance performs.

Adam Pally (Bad Night (2015) and The Mindy Project (2012)); Jeffrey Tambor (Transparent (2014)); fashion designer Nicole Richie. Also: Laura Marling performs.

Joel McHale (Lego Dimensions (2015) and Community (2009)); Rosemarie DeWitt (Poltergeist (2015)).

Kevin Bacon (Cop Car (2015)); Alison Pill (The Family (2016) and Zoom (2015)). Also: Wolf Alice perform.

Carl Reiner; Jason Segel (The End of the Tour (2015) and How I Met Your Mother (2005)); comedian Marc Maron.

Neil Patrick Harris (How I Met Your Mother (2005)); Craig Robinson (Mr. Robinson (2015)).

Lake Bell (Wet Hot American Summer: First Day of Camp (2015)); Chiwetel Ejiofor (The Martian (2015)). Also: Little Mix perform.

Patrick Stewart (Blunt Talk (2015)); the NBA's Anthony Davis. Also: Morrissey performs.

Owen Wilson (No Escape (2015)); Johnny Knoxville (Skiptrace (2016) and "Elvis and Nixon"); Natasha Leggero. Also: Robin Thicke performs.

Ben Kingsley (The Walk (2015) and Collide (2016)); Bill Hader (Trainwreck (2015)); Zac Efron (We Are Your Friends (2015)).

YouTube personalities Tyler Oakley, Jenna Marbles, Kandee Johnson, The Slow Mo Guys; creators of Epic Rap Battles of History (2010). Also: Boyce Avenue perform. Broadcast from YouTube Space LA.