Dr. Sam Griffith takes over as the new chief of surgery after her renowned boss, Dr. Rob "Griff" Griffith, falls into a coma.

Dr. Griffith fights to keep her new leadership role as chief of surgery when her father takes his case for reinstatement to the hospital board. Dr. Caleb Tucker forms an unexpected connection to a patient battling a mystery condition.

When Dr. Sam Griffith tracks down a deep-pocketed anonymous hospital donor, she's shocked to discover why the donor is so loyal to her father, Griff. Also, Griff offers to mentor his daughter and assure her succession.

When a gunshot victim is rushed to the emergency room, the incident triggers flashbacks to the aftermath of Griff's own shooting.

Secrets revealed at a major fundraising gala for the hospital threaten to end a tenuous truce between Dr. Sam Griffith and her father. Cardiothoracic resident Dr. Lex Trulie makes a decision that could alter her career trajectory.

Dr. Griffith deals with the fallout following her actions at the hospital fundraising gala. Griff returns to the operating room for the first time since his shooting to perform a bypass surgery. Malcolm's estranged mother arrives in town.

A devastating storm leads to an overflow of patients and limited resources; Dr. Sam Griffith's team must make impossible choices about their patients' care. Also, Griff connects with a young patient admitted with a rare heart condition.

In the aftermath of a devastating storm, Dr. Sam Griffith and her father, Griff, come together to support her injured mother, Vivian. Also, Dr. Lex Trulie and Dr. Joey Costa each make pivotal decisions about their futures.