In the season three premiere, Dr. Pierce is approached by the FBI to help with a dangerous international case. Plus, Max Lewicki and Dean Paul Haley plot to get Pierce to return to Chicago.

Pierce and Moretti search for a killer when a prosecutor dies in the middle of a courtroom; Moretti and Donnie make some decisions about their future.

Moretti asks Pierce to examine a woman who has confessed to murder and claims to be possessed by the devil; Donnie and Moretti's wedding plans hit a snag.

A gallery owner dies while having a seizure caused by a video installation; Pierce must re-examine his relationship with Natalie.

When an FBI agent is found dead, Pierce must face the one case he was never able to solve; Pierce agrees to help Moretti against the wishes of his therapist.

A sniper at Moretti's office building wounds her friend, and hours later, the first victim's partner is shot, leading Pierce to the back woods of West Virginia in search of a shooter he can relate to.

Donnie wakes up next to dead Shelby, calls Pierce to help him. Pierce and Moretti tries to clear his name. Pierce's father gets mistaken as Ruby's husband. He asks him and Moretti to find her actual husband (a wanted gangster).

After Dr. Daniel Pierce suffers a traumatic injury, his father and his friend must decide if they should allow him to undergo a high-risk surgery; Pierce begins to question everything he sees and hears.

When the owners of a meat company are brutally murdered, agent Kate Moretti goes undercover to investigate.

When Moretti goes missing on the day of her wedding, Pierce and Donnie set out to find her. A dangerous person from Pierce's past abducts Kate.