Neil deGrasse Tyson interviews magicians Penn and Teller and discusses the science of illusion with co-host Chuck Nice and guest Susana Martinez-Conde.

Neil deGrasse Tyson expands his cosmic perspective with actress and activist Susan Sarandon. The two discuss gender, race, perspective, marijuana and Carl Sagan.

Neil deGrasse Tyson interviews musician David Byrne and discusses creativity in the arts and sciences with co-host Maeve Higgins and guest Monica Lopez-Gonzalez.

Neil deGrasse Tyson interviews Mars One co-founder Bas Lansdorp and discusses the idea of establishing a permanent human settlement on Mars with co-host Eugene Mirman and guest Mike Massimino.

Neil deGrasse Tyson interviews David Crosby and discusses folk music and social justice with co-host Chuck Nice and guest Thomas Sugrue.

Neil deGrasse Tyson interviews Gina McCarthy and discusses the EPA's efforts in keeping the Earth habitable for humans with co-host Maeve Higgins and guest Andrew Revkin.