Dwayne Wade returns with guests Gabrielle Union-Wade and La La Anthony to take on new games for charity.

Gabrielle Union-Wade and Lala Anthony might make Cube history; Kweku and Kofi, having seen the Cube destroy many teams last season, are here to avenge the plexiglass they call "Little Cubie."

Wanda Dench shot to viral fame when she accidentally texted stranger Jamal Hinton in error when she intended to invite her grandson over for Thanksgiving; six years on, they hope to be thankful for a $250,000 windfall.

The Cube is faced with a competitor like no other as NBA legend Shaquille O'Neal takes on the Cube in a solo attempt to win money for charity.

The Cube met have met his match when Baltimore BFFs Brianna and Nyah show the Cube a thing or two about attitude.

Best friends and fellow teachers John and Dave set out to teach the Cube a lesson.

Dr. Libby and daughter Kelsey use their family bond to attempt to outwit The Cube.

Cheer coaches Tommy and Jermaine tumble into The Cube bursting with positivity.

Two brothers from San Francisco, Brian and Branden, continue their game with their eyes on the 250k prize.

Youth ministers and married couple Larissa and Luis take on the Cube.

Texas Cowboy's Ben Senior and Ben Junior are out to tame The Cube and bag themselves a quarter of a million dollars.