In the season premiere, which takes place five years after last season's climax, Owen has to reintegrate into normal life at the hospital after spending time in prison. KEEGAN-MICHAEL KEY (Key and Peele, MADtv) guest stars.

The doctors are summoned to the White House, by Lola, to help with a matter of national security.

Shocking DNA test results cause confusion and chaos among the staff.

Nurse Beth enters a love triangle with Glenn and Owen; a high-stakes medical mystery.

Blake asks Glenn to coach him through a new romantic relationship. Chief and Cat prank call Sy. Guest stars include Lindsay Sloane, James Adomian, Paul Scheer, Nick Offerman, and Jordan Peele.

The cast appears on a morning show, "Up at 5," to promote the upcoming Childrens Hospital movie.

Sy runs himself ragged trying to impress an influential blogger.

Val assembles a team to break into Sy's sperm bank vault to steal his prized collection.

Sy's new girlfriend makes significant changes around the hospital.

Owen and Briggs work together on a murder case that has spanned fifteen years; a look into Owen and Briggs' past.

When a newspaper calls Glenn a "rock star surgeon," he worries that he'll die on his upcoming 27th birthday, like so many of his fellow rock stars before him. Meanwhile, Chief opts for a "staycation" at the hospital.

Glenn returns to the Lower East Side of São Paolo, Brazil, for his family's weekly Shabbat dinner. Guest stars include Ben Feldman, Mimi Kennedy, Michael Lerner, Lindsey Kraft, Seth Morris, and Jamie Denbo.

After years of injustice, Blake recognizes that the source of his life's pain is the other doctors and takes revenge.