Holmes learns a secret about Captain Gregson's girlfriend when she hires him for a case she wants kept off of Gregson's radar. Also, Holmes and Watson join the NYPD's search for an abducted woman.

When the city commends the work of Captain Gregson's unit, Gregson pushes for Holmes and Watson to be included; a financial analyst is murdered.

Holmes and Watson investigate a mass murder when a chef and his patrons are poisoned with snake venom. Also, Detective Bell's crush on a work colleague makes Holmes realize his and Fiona's relationship is at an important crossroads.

Joan worries Sherlock's sobriety is at risk when she learns he has been lying to her about attending recovery meetings.

When Shinwell is framed for a gang killing, Holmes and Watson have three days to catch the real killer before Shinwell is sent back to jail.

Watson is implicated in a DEA investigation into doctors writing illegal prescriptions, so she and Holmes look for the culprit using her medical license to sell drugs.

Two watchmen chase a creepy clown into the woods, seconds after losing him they stumble upon his corpse buried in a shallow grave.

Watson is held at gunpoint by father whilst Sherlock is forced to investigate an old assault case of the son. It was botched by the original investigation.

A former professional eSports video game player dies after he's assaulted during a live video stream; Shinwell asks Joan for advice when his daughter asks to see him for the first time in five years.

Holmes' former protégé, Kitty Winter, returns to New York after a three-year absence to warn him that a killer is eliminating everybody involved with a case they worked on.

Sherlock and Joan investigate a case which involves a legendary pirate and his rumored treasure. All while the two struggle with their relationship with Shinwell.

Holmes and Watson investigate the murder of a man Sherlock considered one of New York's worst private investigators.

Holmes and Watson investigate the murder of a magician performing a classic stunt. Watson believes Bell is being targeted by his new girlfriend's ex-husband.

A murder investigation puts Holmes and Watson in the crosshairs of one of NYC's deadliest gangs. A mysterious woman causes Holmes to act erratically.