Holmes and Watson travel to London to help track down an old mentor and investigate an unsolved mystery.

When a well-respected mathematician is found dead, Holmes and Watson set out to solve a murder and the purpose of the highly guarded equation he was trying to decipher.

When Holmes and Watson set out to track down a civil contractor who leaked classified information, their lives are disrupted when they are targeted by the group of cyber-activists protecting him. Tony Award Winner Steve Kazee guest stars.

When dominatrix friend of Sherlock's finds her client dead, Sherlock determines that he had been poisoned.

Holmes and Watson find themselves digging through the dark world of the mob to find a killer when they discover the body of a former assassin.

Captain Gregson's team learns a bit about his personal life after his home is invaded. Holmes and Watson track the gunman.

Sherlock's brother, Mycroft, arrives in New York and enlists Holmes and Watson to help solve a case involving his former fiancee. Meanwhile, Sherlock has a difficult time accepting Mycroft and Joan's relationship.

When a young woman is murdered and it is discovered that she is a "kept woman", Holmes and Watson investigate her ties to a billionaire CEO.

Holmes and Watson uncover the identity of a serial killer whose case has gone cold and find themselves butting heads with the NYPD.

When an investigation goes horribly wrong, Sherlock must testify in an official police inquiry which jeopardizes his and Watson's future with the NYPD.

The kidnapping of a young girl leads Holmes and Watson to a familiar face from the past.

When a body is found in a barrel, Holmes and Watson launch an investigation into the Mafia's ties to the murder. Meanwhile, Sherlock attempts to make amends with Detective Bell. Featuring Peter Gerety and Paul Sorvino.

Holmes' latest investigation takes him inside a professional dance company when an up-and-coming ballerina is murdered. Meanwhile, Watson embarks on a solo enquiry to find a homeless veteran when his friend alleges he was abducted.

Tensions rise when Holmes and Watson are forced to partner with Gareth Lestrade, Sherlock's former Scotland Yard colleague, on a bombing investigation.

Holmes and Watson consult on a case in which a man suspected of murdering his wife years ago receives a ransom demand for her safe return. Meanwhile, Lestrade overstays his welcome at the brownstone and seems unwilling to leave.

When a famous cancer researcher is found dead, Holmes and Watson must determine if the scientist's untimely demise was tied to his latest cutting-edge invention. Meanwhile, Bell is finally cleared to re-enter the field.

A serial killer known for biting his victims appears to be killing again, even though he was presumed dead.

Holmes and Watson must find the source of anthrax that may be used for a terrorist attack.

When Sherlock's brother Mycroft makes a surprise return to New York, his motivations cause discord between Sherlock and Joan. Meanwhile, a missing person case takes Sherlock and Joan inside the world of unmanned aeronautics.

With Watson kidnapped, the Holmes brothers are extorted to buy her back by acquiring something the gangsters greatly value. As the clock runs down on Watson's life, Sherlock is forced to work with his despised brother Mycroft.

Mycroft's handler at MI6 asks Sherlock to investigate the death of a mentally disturbed operative. Watson tries to cope with her feelings about the kidnapping, as well as Mycroft's deceptions.