Pregnant with her first child, Traci is desperate to move back into her childhood home. But it's filled floor to ceiling with her mother's stuff. Now the two must work together to clear a decades worth of clutter before it's too late.

Compulsive hoarder Kathleen discovers a hoard of mice living in her kitchen numbering in the thousands. And for extreme hoarder Jaime's future son-in-law, spending the night in a hoard might very well end a marriage before it even begins.

Extreme Hoarder Renee almost died when emergency workers responding to a 911 call were unable to get through her front door. With her home now declared unlivable by the authorities, Renee knows she needs to make a change.

The unsafe conditions in and around the home of extreme hoarder Floyd have been brought to the attention of Child Protection Services. Now he must clear his hoard or risk losing his three-year-old son Charlie.

Sherry's hoard has broken up her marriage. Now, authorities are threatening to take away her children and condemn her home. With only weeks to clean it up, Sherry could lose everything she loves.

Hsi Ming and Miranda are both mothers and extreme hoarders. Miranda's obsession has left her twin toddlers with no room to play amongst the hoard. Hsi-Ming's daughter is concerned for the health and safety of her mother.

Celia is a psychologist who helps other but can't solve her own hoarding problem. Now she's losing the battle against her stuff and the millions of roaches infesting her home.

Phyllis' neighbors are complaining about the trash bags piling up outside of her home, while the inside of her home is so packed that she can barely move around. Faye, who suffers from COPD, realizes her hoard is killing her.