Michael works double duty trying to save a pregnant personal friend he recently diagnosed with a brain tumor and a little boy with sickle cell disease.

When Michael treats a patient who is hearing voices, he turns to Anton for help. Meanwhile, Kate's first day at the clinic doesn't go well.

Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.

Dr. Barnes and Dr. Sykora save a man on a bus who turns out to have a DNR order. Meanwhile, Rita's son has a motorcycle accident that reveals an existing medical condition.

While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.

Michael saves a man from drowning and learns his identity is a mystery.

A distraught woman takes the Clinica staff hostage after Michael testifies for a former patient who he believed suffered uncontrollable urges due to a brain tumor.

When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.

When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.

Michael learns that a patient at the clinic has a special connection to Anna. (Frances Fisher guest stars)