Kara is surprised to find CatCo has a new owner who has brought in a star reporter; new couples emerge and explore their budding relationships; J'onn J'onzz receives an unexpected visitor.

Supergirl, Alex and Brainiac thwart an alien attack while William investigates Kara; J'onn J'onzz and Kelly use Obsidian tech to solve a problem.

Kara tries to mend her relationship with Lena; J'onn J'onzz takes a deep dive into his memories; Kelly tries to help an old friend.

Kara's investigation into William Dey's "criminal" activities results in the shocking revelation he is not who she thinks. Meanwhile, the conflict between Malefic and J'onn J'onzz reaches a boiling point.

On the eve of the worldwide launch of Andrea Rojas's VR contact lenses, Kara and William team up on an investigation that exposes a terrorist plot. Kelly and Alex celebrate an anniversary, but Alex's safety is in jeopardy.

While a new villain is under arrest at the DEO, Supergirl uses him to try and understand who is responsible for the recent attacks. Meanwhile, Andrea and Lena think back on their tumultuous past.

Supergirl finally learns the truth about Lena while tangling with Leviathan; J'onn J'onnz makes a discovery about his brother's whereabouts.

Supergirl's struggle against Leviathan reaches a boiling point as she faces off against Rama Khan. Meanwhile, as Lena and Hope work to launch Project Non Nocere, Hope proves to be an invaluable asset to Lena.

The subsequent complications from the Crisis leave Supergirl to face a chaotic threat.

Winn Schott returns from the future just as Supergirl is pursuing a Toyman copycat.

Supergirl helps Winn overcome his greatest fear; Brainy must choose whether to help Alex find evidence against Lex or continue secretly working for him.

Mxyzptlk returns with a proposition for Kara; Kara must decide if she wants to change history to become friends with Lena again.

Lex tasks Supergirl with protecting Andrea from an anti-tech extremist; Lena moves forward with Non Nocere, with Lex's help.

Nia's roommate is attacked by a man targeting Dreamer; Dreamer refuses to give into men's threats and puts herself in the line of fire to stop him; Alex, J'onn and Kelly attempt to rescue a man stuck inside a virtual reality game.

Alex uses a pair of Obsidian contact lenses to visit a virtual National City where she takes on a whole new persona. Meanwhile, Kelly helps William investigate Lex. Kara deals with difficult news.

Supergirl and the team go head-to-head against Rama Khan and Leviathan; Lena and Lex must join forces when Project Non Nocere fails, leaving the two siblings in serious danger.

Supergirl realizes that she must work with Lena to stop Lex and Leviathan; Nia struggles with what her dreams are trying to tell her; Brainy realizes there is only one way to stop Lex.