Surgical resident Dr. Grace Devlin (Jordana Spiro) juggles her promising medical career with a secret deal to offer her medical services to a mob boss in order to save her ne'er-do-well younger brother's life.

After treating a family that was involved in a fatal car accident, Grace (Jordana Spiro) is stunned when Constantine (William Forsythe) orders her to treat the hit-and-run driver's injuries, too.

As she fights for a critically ill woman's heart transplant, Grace (Jordana Spiro) is asked to kill her patient's estranged and imprisoned father in order to get the organ she needs to save her life.

An exiled mobster's return to Chicago draws Grace (Jordana Spiro) into the middle of a looming showdown between Constantine (William Forsythe) and undercover cop Franco (James Carpinello).

As she struggles to stay out of a brewing gang war, Grace is tapped to treat Brett's estranged brother following a bicycle accident. Nate turns to his sister after he accidentally jeopardizes a mobster's valuable racehorse.