After a failed suicide attempt, Ryan notices that he sees the neighbor's dog as a person wearing a dog costume.

Wilfred is angry after Ryan tricks him into going to the veterinarian.

Ryan discovers Wilfred left his wallet outside when they broke into Spencer's house.

Ryan feels obligated to repay his sister's help, however inappropriate, and therefore must shortly hand Wilfred into Darryl's daycare. The dog feels neglected and behaves strangely depressed.

Wilfred persuades Ryan to help him get rid of Jenna's boyfriend.

Wilfred's pursuit of a new love interest forces Ryan to swallow his pride - among other things.

When Wilfred learns that Ryan feels responsible for the death of his beloved childhood dog, he goes to otherworldly lengths to help Ryan learn the truth.

Ryan's resentment of his eccentric mother is exacerbated when Wilfred starts treating her like the mum he never had.

Wilfred uses Ryan's unhealthy habit of isolating as a means to rid himself of a neighborhood pest.

Ryan begins to suspect that his friendship with Wilfred may be self-destructive.

Wilfred urges Ryan to sacrifice his newfound happiness for a greater good.

Ryan ignores Wilfred's advice, creating an existential crisis for both of them.